(COMBO) This combination of file pictures created on March 4, 2021 shows Britain's Prince Harry and US actress Meghan Markle at Kensington Palace in west London on November 27, 2017 following the announcement of their engagement, and US media executive and talk show host Oprah Winfrey as she arrives to the opening celebration of the Statue of Liberty Museum on Liberty Island in Battery Park in New York on May 15, 2019. - He may be the Queen's grandson, but she is American cultural royalty: Oprah Winfrey, whose upcoming bombshell interview with Prince Harry and Meghan Markle is dominating headlines, is a billionaire TV phenomenon renowned for coaxing secrets and tears from countless celebrities. From Michael Jackson and Tom Cruise to Lance Armstrong and the Duchess of York, Winfrey is responsible for some of America's most memorable sit-down interviews over the last three decades. Harry and Meghan are the latest to open up when a tell-all interview with the talk show queen is aired by CBS on March 7, 2021. (Photos by Daniel LEAL-OLIVAS and Kena Betancur / AFP)