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Computer illustration of the anatomy of the human digestive system and a close-up view of Escherichia coli bacteria. E. coli is one of the main components of the human intestinal microbiome. E. coli are Gram-negative motile bacteria of the Enterobacteriaceae family. They colonise the jejunum, ileum and other parts of the intestine. Some strains of E. coli cause diarrheal diseases and inflammation at different locations.