This illustration depicts a three-dimensional (3D) computer-generated image of five drug-resistant Salmonella serotype Typhi bacteria. The artistic recreation was based upon scanning electron micrographic imagery. Note the presence of numerous thin, short fimbriae emanating from the organisms? cell wall, imparting a furry appearance to these bacteria, and the multiple peritrichous flagella, i.e., flagella protruding in all directions from the cell wall, which provide the bacteria with a mode of motility. Salmonella serotype Typhi causes typhoid fever, a potentially life-threatening disease. People with typhoid fever usually have a high fever, abdominal pain, and headache. Typhoid fever can lead to bowel perforation, shock, and death. Physicians rely on drugs such as ceftriaxone, azithromycin, and ciprofloxacin for treating patients with typhoid fever, however, Salmonella serotype Typhi is showing resistance to: ceftriaxone, azithromycin, ciprofloxacin, to which resistance is so common that it cannot be routinely used.