(COMBO) This combination of file pictures created on March 4, 2021 shows US TV personality Oprah Winfrey speaking on April 7, 2015 at the Warner Theater in Washington, DC, and Britain's Prince Harry (R) and his fiancee US actress Meghan Markle attending a Commonwealth Day Service at Westminster Abbey in central London, on March 12, 2018. - He may be the Queen's grandson, but she is American cultural royalty: Oprah Winfrey, whose upcoming bombshell interview with Prince Harry and Meghan Markle is dominating headlines, is a billionaire TV phenomenon renowned for coaxing secrets and tears from countless celebrities. From Michael Jackson and Tom Cruise to Lance Armstrong and the Duchess of York, Winfrey is responsible for some of America's most memorable sit-down interviews over the last three decades. Harry and Meghan are the latest to open up when a tell-all interview with the talk show queen is aired by CBS on March 7, 2021. (Photos by NICHOLAS KAMM and Daniel LEAL-OLIVAS / AFP)