TOPSHOTS Pope Francis rides through Santiago de Cuba, in eastern Cuba, towards to airport on September 22, 2015. Pope Francis left Cuba Tuesday for his first-ever visit to the United States, where he may get a slightly chillier reception in some quarters than on the Caribbean island. Cuban President Raul Castro saw him off at the airport after a four-day visit that featured three cities, three masses, countless handshakes with adoring crowds, and meetings with both Castro and his big brother Fidel, the men who have ruled the communist island since its 1959 revolution. AFP PHOTO / POOL / ALEJANDRO ERNESTO