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Starling in the midst of an experiment upon circulation with a dog. No date or location given. Ernest Henry Starling (1866-1927) was an English physiologist. His main collaborator was his brother-in-law, William Maddock Bayliss. His major contributions to physiology were: the Starling equation, describing fluid shifts in the body, the discovery of peristalsis (with Bayliss), the discovery of secretin, the first hormone (with Bayliss), the introduction of the concept of hormones and the discovery that the distal convoluted tubule of the kidney reabsorbs water and various electrolytes. Starling is most famous for developing the "Frank-Starling law of the heart", presented in 1915 and modified in 1919. He is also known for his involvement along with Bayliss in the Brown Dog affair, a controversy relating to vivisection. He died in 1967 at the age of 61.