Print entitled: Attack on the Massachusetts 6th at Baltimore, April 19, 1861. The Baltimore riot of 1861 (also called the Pratt Street Riot and the Pratt Street Massacre) took place on April 19, 1861, in Baltimore, Maryland between Confederate sympathizers and members of the Sixth Massachusetts Regiment. It is regarded by historians as the first bloodshed of the American Civil War. The Union's Sixth Massachusetts Regiment was traveling south to Washington, D.C. through Baltimore. A mob of secessionists and Southern sympathizers attacked the rear companies of the regiment with bricks, paving stones, and pistols. Several Union soldiers fired into the mob, and thus began a giant brawl began between the soldiers, the mob, and the Baltimore police. Four soldiers and 12 civilians were killed.