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Patient with smallpox (variola) and close-up of a smallpox virus, illustration. Smallpox is a disease that causes fever and often death. It was eradicated after a worldwide effort in the 1970s, but strains exist in research laboratories. Similar skin lesions can be found in currently available viruses from the Poxviridae family, such as monkeypox, which also have the same virion morphology.